Browsing by Author "W. Ouma, J.O."

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Alternative Complement Pathway Activity in Experimental Surra
(1998) W. Ouma, J.O.; Olaho-Mukani, W.; Whishitemi, B.E L.; Guya, S.O.; Kenya Trypanosomiasis Research Institute; Division of Biochemistry and Immunology, Kenya Trypanosomiasis Research Institute
Haemolytic complement activity in dromedary camels Infected with Trypanosoma evansi was assayed under alternative pathway conditions. Complement fixing antibody titres and circulating trypanosomal antigen levels were also monitored throughout the infection period. A rapid initial increase (47%) in mean alternative pathway haemolytic complement (ACH5o) level occurred during the first week of infection. ACH50 levels later decreased significantly in infected camels and recovered only after drug treatment was started. The mean ACH 50 units of un-infected control camels showed only slight variations throughout the study and were significantly higher than those of infected camels (p