Browsing by Author "Bailey, K.P."
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Item Experiments in Immunity to East Coast Fever(1965) Brocklesby, D.W.; Bailey, K.P.; Jarrett, W.F.H.; Martin, W.B.; Miller, H.R.P.; Nderito, P.; Urquhart, G.M.; University of East Africa, P.O. Kabete, KenyaSpleen suspension from cattle in the late hyper-plastic stage of Theileria parva infection, injected i/v in doses of 0.1-5 ml., protected 15 of 19 cattle from tick-induced infectionItem A Mild form of East Coast Fever (Theileria Parva Infection) Becoming Virulent on Passage through Cattle(1968) Brocklesby, D.W.; Bailey, K.P.; East African Veterinary Research Organisation, Muguga, P.O. Kabete, KenyaA mild strain of Theileria parva isolated from some unknown wild animal became virulent at the tenth passage in cattle; at the eighteenth passage level it was indistinguishable from the standard laboratory strain.Item Oxytetracycline Hydrochloride in East Coast Fever (Theileria Parva Infection)(British Veterinary Journal, 1962) Brocklesby, D.W.; Bailey, K.P.; East African Agriculture and Forestry Research OrganizationTwenty-one cattle of European breeds were infected with T. parva by placing infected Rhipicephalus appendiculatus ticks on the ears. They were given one of the following treatments: - (A) soluble powder with a sucrose base, containing 25 g. oxytetracycline hydro-chloride [OTC] per pound, dissolved in water and given orally at 15 mg. OTC per kg. body wt. for 28 days following infection; (B) finely-milled corn meal containing 10 g. OTC per Ib. suspended in water and given at the same dosage; (C) intraperitoneal inj. of a solution of OTC in saline, at 10 mg. per kg. on alternate days during incubation and daily during the febrile period; (D) the same i/p inj., daily after the onset of fever; (E) oxytetracycline magnesium complex in propylene glycol, inj. i/v at 10 mg. OTC per kg. daily after the onset of fever. Treatment was maintained until parasites disappeared from the blood or until the animal died. Only one of the 9 cows given treatments A, B and C died. The incubation period was prolonged; it averaged 16.7 days. All were immune to challenge immediately after recovery. Treatments D and E appeared to be ineffective, since 7 of 8 died. There appeared to be a critical period during incubation, after which treatment was ineffective The method recommended to protect valuable stock during an outbreak was oral administration of the soluble powder.Item Parthenogenesis not Significant in the Life Cycle of the Tick Rhipicephalus Appendiculatus(1961) Brocklesby. D.W.; Bailey, K.P.Dr. H. Hoogstraal (1960, personal communication) pointed out that Bailey (1960), by stating: "Although female R. appendiculatus alone will feed on a rabbit and later produce eggs, we have found that we get a better average yield of eggs if a number of male R. appendiculatus are included, together with the females ", had implied that parthenogenesis could occur in the life cycle of this species of tick. We therefore performed experiments to check this.Item The Transmission of East Coast Fever Using Cells from Infected Animals(1964) Jarrett, W.F.H.; Jennings, S.; Martin, W.B.; Urquhart, G.M.; Nderito, P.; Brocklesby, D.W.; Bailey, K.P.; University of Glasgow Veterinary Hospital, Glasgow (U.K.); Veterinary Faculty, University of East Africa; E.A.V.R.O. Muguga (Kenya)This chapter describes the transmission of east coast fever using cells from infected animals. Four experiments using 26 cattle were carried out. In the first, a suspension of spleen and lymph node cells was prepared from a field case which was in the late hyperplastic stage of the disease. It was implanted interperitoneally into two animals, both of which showed a typical severe clinical and pathological reaction. They were killed in the late hyperplastic stage and cell suspensions prepared from their spleens. Two further passages were then carried out using a similar technique but smaller volumes of cells. It is found that of the 16 animals infected, 7 died, or were killed in extremis, 6 reacted severely and recovered, while 3 showed a clinical reaction but did not have demonstrable parasites. In the second experiment, cells from a field case were implanted by the interperitoneal route into an animal, and when this was in extremis it was killed and a cell suspension was prepared. The intravenous route was then used successfully to infect two other cattle.
