Browsing by Author "Cunningham, M. P."
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Item Detection of Antibodies in Blood Meals of Hematophagous Diptera(1962) Cunningham, M. P.; Harley, J. M. B.; Southon, H.A.W.; Lumsden, W.H.R.; East African Trypanosomiasis Research Organization, Tororo, UgandaAntibodies are detectable by an agglutination technique in the blood meals of hematophagous Diptera that are fed on laboratory and domestic animals infected with organisms of the Trypanosoma bruccei subgroup. It is likely that both the antibody status and the identity of the animal fed on can be determined from the same blood meal from wild Diptera. The technique may be applicable to other infections for which sensitive serological tests are available.Item The Estimation of IgM Immunoglobulin in Dried Blood, For Use as a Screening Test in the Diagnosis of Human Trypanosomiasis In Africa(1967) Cunningham, M. P.; Bailey, N. M.; Kimber, C. D.Mattern (1964) has shown that in human trypanosomiasis caused by Trypanosoma gambiense, the serum IgM immunoglobulin level is consistently raised, and this was confirmed by LUMSDEN (1965) for infection with T. rhodesiense. Although these authors showed that increased levels of serum IgM are not pathognomonic for trypanosomiasis, the observation that low levels virtually exclude the possibility of trypanosome infection is obviously relevant to the development of a screening test for diagnosis.Item Preservation of Viable Trypanosomes in Lymph Tubes at Low Temperature(1963) Cunningham, M. P.; Lumsden, W. H. R.; Webber, W. A. F.; East Africa Trypanosomiasis Research Organization, Tororo UgandaA simple method for the preservation of viable trypanosomes at a low temperature (about -80a C) is described. Trypanosome suspensions, containing 7.50/0 glycerol by volume, are distributed in about 25-mg quantities to lymph tubes. The tubes, after sealing, are cooled slowly. The method has been found effective with blood, culture, and fly forms of the Trypanosoma brucei Subgroup, with blood forms of the T. congolense and T. vivax groups, and with culture forms of T. cruzi.Item Trypanosomiasis in African Wild Animals(1968) Cunningham, M. P.; Food and Agriculture OrganizationThree-quarters of Africa south of the Sahara is infested with the Tsetse fly. General speaking, because of the trypanosomes transmitted by these flies. where there are Tsetse flies there are no cattle. Tanzania is a good example. If the maps showing distribution of cattle and Tsetse flies in the Atlas of Tanzania ape consulted. it will be seen that one is the reverse of the other. In Tsetse-infested areas. the flies feed on wild animals which are often present in large numbers, and in these animals the pathogenic African trypanosomes are maintained
