Browsing by Author "Eckersall, P.D."
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Item Elevation of the concentration of acute phase proteins in dogs infected with Trypanosoma brucei(1991) Ndungu, J. M.; Eckersall, P.D.; Jennings, F. W.; Kenya Trypanosomiasis Research Institute; Department of Veterinary Medicine, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH, U.K.Plasma concentrations of the acute phase proteins (APP), C-reactive protein (CRP) and haptoglobin (Hp), increased markedly following experimental infection of dogs with Trypanosoma brucei. The highest concentrations of CRP were observed immediately after peaks of parasitaemia. Treatment with curative doses of the trypanocidal drug suramin caused a rapid decrease in CRP. Relapse infections after subcurative treatment were followed by a reappearance of high plasma CRP concentrations. Haptoglobin remained elevated during the course of the disease. Curative treatment with suramin caused a gradual but slow decrease in Hp while subcurative treatment caused no significantly changes. Thus, the estimation of CRP was useful in determining the presence of active infection and the success of chemotherapy. High Hp levels in severely anaemic dogs indicated that intravascular haemolysls does not contribute significantly to the anaemia associated with T. brucei infections in dogs. These conclusions need confirmation from a larger experiment.
