Browsing by Author "GOODWIN, L. G."
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Item Further development of a method to isolate intracellular stages of Trypanosoma cruz; from infected rats(1975) GOODWIN, L. G.; Nuffield Institute of Comparative Medicine, The Zoological Society of London, Regent's Park, London, N.W.1 UKInvestigations of amino acid utilization during growth of T. brucei S42 in defined media have revealed the existence of a hitherto unreported and potentially important pathway for carbon assimilation. Large amounts of threonine were metabolized with concomitant excretion of approximately equimolar amounts of glycine. The amount of threonine metabolized was typically 20-fold greater than the amount of proline metabolized, and 4-fold greater than the dry weight of cellular material synthesized during the same period. Use of radioactively-labelled threonine confirmed the origin of the excreted glycine, and it was further demonstrated that the remaining half of the molecule was converted to acetate.Item Pathological Effects of Trypanosoma Brucei on Small Blood Vessels in Rabbit Ear-Chambers(1971) GOODWIN, L. G.; Nuffield Institute of Comparative Medicine, The Zoological Society of London, Regent's Park, London, N.W.1 UKInfection with trypanosomes of the Trypanosoma brucei subgroup causes the liberation of short-chain peptides with kinin-like activity in mice, rats, rabbits and cattle (GOODWIN and RICHARDS, 1960; RICHARDS, 1965; BOREHAM, 1966, 1968) and also in man (BOREHAM and GOODWIN, 1969). The release of kinin is associated with antigen: antibody reactions and may be responsible for changes in vascular permeability that lead to the production of oedema. A study of the blood vessels of the ears and the cremaster muscles of rabbits showed that infection with T. brucei led to a chronic vasculitis (GOODWIN and HOOK, 1968).Item The Pathology of African Trypanosomiasis.(1970) GOODWIN, L. G.; Nutfield Institute Comparative Medicine, the zoological society of London Regents Park LondonI must, at the beginning of this paper, acknowledge the immensely valuable support given to work on all aspects of trypanosomiasis by the British Ministry of Overseas Development. From colonial times, the authorities have recognized the threat of this dangerous disease to man and his domestic animals, and also the fact that its study involves the disciplines of human medicine, veterinary medicine, mammalogy and entomology in equal measures. The Ministry has continued to initiate and to support research projects in Britain and overseas and it holds seminars at which progress is assessed. One of its latest achievements has been to sponsor a book, The African Trypanosomiases edited by Colonel H. W. MULLIGAN and Mr. W. H. POTTS (1970), into which the accumulated field and laboratory experience of British workers in all aspects of trypanosomasis has been distilled. It is on the brink of publication and contains so much wisdom that it is certain to become an 'instant' classic. It would therefore seem somewhat pretentious for me to present a paper, at this particular time, on any aspect of the disease. But trypanosomiasis has not been considered by a full Meeting of this Society for several years, and I hope that this evening's discussion may serve as an aperitif to whet your appetites for what is to come.
