Browsing by Author "Kirimi, I.M."
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Item Observations on the Cross-Immunity between Theileria Lawrencei (Serengeti) and Theileria Parva (Muguga) in Cattle(1973) Young, A.S.; Brown, C.G.D.; Burridge, M.J.; Cunningham, M.P.; Kirimi, I.M.; Irvin, A.D.; East African Veterinary Research Organization, Muguga, P.O. Kabete,KenyaObservations on the cross-immunity between Theileria lawrencei (Serengeti) and Theileria parva (Muguga) in cattle. Internationaljournal for Parasitology3: 723–728. Cattle immunized against Theileria parva (Muguga) showed little resistance to Theileria lawrencei (Serengeti) stabilate challenge, while cattle immune to T. lawrencei (Serengeti) were fully resistant to challenge with T. parva (Muguga) stabilate. Cattle inoculated with cultured lymphoid cells infected with T. lawrencei (Serengeti) macroschizonts survived a subsequent T. lawrencei (Serengeti) stabilate challenge.Item Preliminary Studies on an Atypical Strain of Bovine Theileria Isolated in Kenya(1974) Burridge, M.J.; Brown, C.G.D.; Crawford, J.G.; Kirimi, I.M.; Morzaria, S.P.; Payne, R.C.; East African Veterinary Research Organization, PO Box 32, Kikuyu, Kenya FAO/UNDP Project KEN 22, Veterinary Research Laboratory, PO Kabete, KenyaA theilerial parasite infective for cattle, Theileria sp. (Githunguri), was isolated from the Kiambu District of Kenya through Rhipicephalus appendiculatus ticks. Eight cattle were experimentally infected with Theileria sp. (Githunguri); their reactions were characterized by the production of low numbers of macroschizonts, no microschizonts, few or no piroplasms, and a transient febrile response. All these cattle recovered from clinically mild reactions to infection, but were fully susceptible to subsequent Theileria parva (Muguga) challenge. A cell culture isolate of Theileria sp. (Githunguri) was made from injected lymphoid cells of a reacting animal and, from the resultant in vitro culture suspension, a schizont antigen of the parasite was prepared for the indirect fluorescent antibody test. Serological studies on Theileria sp. (Githunguri), using this test, indicated that it was antigenically distinct from T. parva, T. lawrencei and T. mutans, but had some antigens in common with T. parva and T. lawrencei.Item Theileriosis: The Exposure of Immunised Cattle in Atheileria Lawrencei Enzootic Area(1974) Cunnigham, M.P.; Brown, C.G.D.; Burridge, M.J.; Irvin, A.D.; Kirimi, I.M.; Purnell, R.E.; Radleys, D.E.; Wagner, G.G.; East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, KenyaThree groups of steers were exposed to field challenge in a T. lawrencei-enzootic area of Kenya. Four out of five ECF-susceptible steers and four out of five steers immunised against T. parva (Muguga) died of theileriosis, the surviving animals experiencing severe reactions. On the other hand, all five steers immunised against T. parva (Muguga) and a strain of theileria probably homologous with the one present in the area of exposure, survived and only experienced mild reactions. These results indicated that immunisation of cattle with T. parva (Muguga) may not necessarily protect them against field challenge with certain T. lawrencei-type strains, but that immunisation with an apparently homologous strain of theileria may well do so.
