Browsing by Author "Linyonyi, A."
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Item The Effects of Levamisole on The Immune Response And Disease Course In Mice Infected With Trpanosoma Brucei(Arthur Linyonyi, 1981) Linyonyi, A.; University of LiverpoolTrypanosomes are protozoan parasites of many species of animals, including some non-mammals (Norm6n, 1973). They occur as blood and tissue parasites, ranging from the very pathogenic to a pathogenic types, such as Trypanosoma theileri (Laveran, 1902) in cattle and T. lewisi" (Kent, 1880) in the genus Rattus •Item Immunisation Of Small-Holder Cattle Against East Coast Fever In Kiambu District, Kenya(1994) Linyonyi, J.M.; Kariuki, D.P.; Rumberia, R.M.; Mbogo,S.K.; Linyonyi, A.; KARI ( National Veterinary Research Centre P.o Box 32 kikuyu )Three hundred and fifty-eight head of cattle were immunized against East Coast fever using the 'infection and treatment method' in small holdings in Kiambu District. It was observed that the animals could be successfully monitored once every 3 days instead of daily as was done previously. The reaction rate was higher in calves than in adults; thet incidence of other tick-borne diseases did not: increase after immunization despite a relaxation in’ tick control efforts.Item Responses to a vaccine trial for East Coast fever in two cattle herds at the Kenyan coast(1991) Mutugi, J.J.; Ndungu, S.G.; Linyonyi, A.; Maritim, A.C.; Mining, S.K.; Ngumi, P.N.; Kariuki, D.P.A total of 373 cattle (271 Zebu-European crosses and 102 pedigree Jerseys) were immunized against East Coast fever on two farms in the Kilifi District of Coast Province, Kenya. The cross breeds and the Jersey cattle received I ml of either 10-01 or 10-' dilution of Thellena parva parva Marikebuni stock, respectively and simultaneous treatment with a long-acting formulation of oxytetracycline. Following immunization, 362 cattle (96.5%) showed Theileria parva antibodies; 346 cattle (92.7%) seroconverted without clinical reactions. The Jersey cattle developed a higher proportion of clinical East Coast fever reactors (14.7%) following the immunization than the cross breeds (0.6%). All the calves immunized (37) on both farms seroconverted to Theileria parva antigen without any theilerial clinical reactions. The development of a serological response to East Coast fever was independent of the route of stabilate inoculation and was unaffected by concurrent infections such as trypanosomiasis and foot and mouth disease. Following immunization, no discernable effects on milk production were recorded, except from cattle undergoing a clinical reaction, where a transient reduction in milk production was seen. Thirty months later, the immunized cattle are reported to have withstood the disease challenge presented to them naturally on the farms without any breakdown in immunity to East Coast fever.
