Browsing by Author "Nderito, P."
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Item Experiments in Immunity to East Coast Fever(1965) Brocklesby, D.W.; Bailey, K.P.; Jarrett, W.F.H.; Martin, W.B.; Miller, H.R.P.; Nderito, P.; Urquhart, G.M.; University of East Africa, P.O. Kabete, KenyaSpleen suspension from cattle in the late hyper-plastic stage of Theileria parva infection, injected i/v in doses of 0.1-5 ml., protected 15 of 19 cattle from tick-induced infectionItem The Transmission of East Coast Fever Using Cells from Infected Animals(1964) Jarrett, W.F.H.; Jennings, S.; Martin, W.B.; Urquhart, G.M.; Nderito, P.; Brocklesby, D.W.; Bailey, K.P.; University of Glasgow Veterinary Hospital, Glasgow (U.K.); Veterinary Faculty, University of East Africa; E.A.V.R.O. Muguga (Kenya)This chapter describes the transmission of east coast fever using cells from infected animals. Four experiments using 26 cattle were carried out. In the first, a suspension of spleen and lymph node cells was prepared from a field case which was in the late hyperplastic stage of the disease. It was implanted interperitoneally into two animals, both of which showed a typical severe clinical and pathological reaction. They were killed in the late hyperplastic stage and cell suspensions prepared from their spleens. Two further passages were then carried out using a similar technique but smaller volumes of cells. It is found that of the 16 animals infected, 7 died, or were killed in extremis, 6 reacted severely and recovered, while 3 showed a clinical reaction but did not have demonstrable parasites. In the second experiment, cells from a field case were implanted by the interperitoneal route into an animal, and when this was in extremis it was killed and a cell suspension was prepared. The intravenous route was then used successfully to infect two other cattle.
