Browsing by Author "Stagg, D. A."
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Item The Incidence of Theilerial Parasites in East African Buffalo (Syncerus caffer)(1978) Young, A.S.; Brown, C.G.D.; Burridge, M.J.; Grootenhuis, G.K.; Kanhau, G.K.; Purnell, R.E.; Stagg, D. A.; Immunological Research on Tick-borne Cattle Diseases and Tick Control Project; East African Veterinary Research Organization245 buffalo from 13 areas of East Africa were examined for theilerial infections, The vast majority of buffalo (97,1%) examined had piroplasms in their erythrocytes. Theileria lawrencei was isolated from the buffalo by tick feeding and cell culture and was found to be common in most of these buffalo populations. Also over 50% of the buffalo had indirect fluorescent antibody (IF A) titres to T. lawrencei. T. mutans was only isolated from 3 buffalo populations but is probably common.Item Synchronization of the division of Theileria macroschizonts and their mammalian host cells(Annals of Tropical Medicine and Parasitology, 1980) Stagg, D. A.; Chasey, D.; Morzaria, S. P.; Dolan, T. T. ; Veterinary Research Department, Kenya Agricultural Research Institute, Muguga; Veterinary Research Department, Kenya Agricultural Research Institute, Muguga; Central Veterinary Laboratory, New Haw, Weybridge, Surrey, U.K.Theileria macroschizonts transform the parasitized lymphoid cells of their mammalian host’s in vivo and ill litro so that the cells become lymphoblastoid, there is a massive proliferation of infected cells and new antigens arc expressed on the cell surface (Brown et at., 1973; De: Martini and Moulton, 1973; Pearson et al., 1979). During the division of the host cells in litro the macroschizonts normally abo divide so that two infected daughter cells are produced (Hulligcr et al., 1964). The end product of macroschizont division in Vivo, and ccasionally ill 1'ltro, is the microschizont and the resultant merozoites are released with the destruction of the host cell.Item Transplantation of bovine lymphosarcoma cells to athymic (nude) mice(1977) Irvin, A.D.; Brown, C. G. D.; Kanhai, G.K.; Stagg, D. A.; UNDP/FAO Tick-borne Diseases Project, East African Veterinary Research OrganizationBovine lymphosarcoma cells, previously established in culture, were inoculated subcutaneously into groups of irradiated and non-irradiated athymic (nude) mice. Tumours developed at the site of inoculation in all of the irradiated mice but in none of the others. Tumour growth was progressive in all cases but there was no evidence of invasion of surrounding tissues nor of metastasis. Tumour cells were passaged directly to further mice and a similar growth pattern was recorded. The use of this system suggests a possible small animal laboratory model for bovine lymphosarcoma
