Browsing by Author "Wishitemi, B.E.L."
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Item Changes in classical pathway complement activity in dromedary camels experimentally infected with Trypanosoma evansi(1997) Ouma, J.O.; Olaho-Mukami, W.; Wishitemi, B.E.L.; Guya, S.O.; Kenya Trypanosomiasis Research Institute; Division of Biochemistry and Immunology, Kenya Trypanosomiasis Research Institute, P.O. Box 362, Kikuyu, Kenya Department of Zoology, Moi University, P.O. Box 1125, Eldoret, KenyaThe complement system is known to have important effector functions in immune responses. However, its role in camel trypanosomosis has not been detennined. The present study was undertaken to evaluate haemolytic complement activity in Trypanosoma evansi-infected and uninfected camels. Five dromedary camels were experimentally infected with T. evansi and classical pathway haemolytic complement activity was assayed. Parasitaemia and packed cell volume were also monitored. Following infection, classical pathway haemolytic complement showed a slight initial increase (7%) in all the camels. The amounts later dropped as the infection progressed and correlated negatively with parasitaemia. Haemolytic complement recovered following elimination of trypanosomes by treatment with melarsomine. Treatment of uninfected camels had no effect on complement. This study has demonstrated that complement concentration increases in the initial phase of infection followed by a drop as the infection progresses towards chronicity. In addition, the study has shown that activation of the classical complement pathway occurs in camels infected with T. evansi. Complement could therefore be involved in the in vivo control of parasitaemia in dromedary camels infected with T. evansi. Decreased complement levels in this species could lead to immunosuppression, widely reported in animal trypanosomosis.
