A third antigenic component associated with foot-and-mouth disease infection

Abstract

A third antigen is produced in tissue cultures of baby hamster kidney (BHK) cells and tissues of guinea pigs and cattle infected with type A foot-and-mouth disease virus (FMDV). This antigen is distinct from the recognized 140 Sand 12 S antigenic components of FMDY. It does not appear to be a virus constituent but is produced as a consequence of the infection; therefore, it has been termed the "virus infection associated" (VIA) antigen. Guinea pigs and cattle infected with Fl\IDV produce antibody to VIA antigen that can be demonstrated by agar gel precipitin techniques; whereas animals immunized with inactivated preparations of Fl\IDY do not. This further suggests it to be an infection-associated material.