Differential Susceptibility to DL-a-Difluoromethylornithine in Clinical Isolates of Trypanosoma brucei rhodesiense

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dc.bibliographicCitation.endpage1188en
dc.bibliographicCitation.issue6
dc.bibliographicCitation.stpage1183en
dc.bibliographicCitation.titleAntimicrobial Agents And Chemotherapyen
dc.bibliographicCitation.volume34
dc.contributor.authorBacchi, C.J.en
dc.contributor.authorNathan, H.C.en
dc.contributor.authorLivingstone, T.en
dc.contributor.authorValladares, G.en
dc.contributor.authorSaric, M.en
dc.contributor.authorSayer, P.D.en
dc.contributor.authorNjogu, A.R.en
dc.contributor.authorClarkson, A.B. Jren
dc.contributor.corpauthorKenya Trypanosomiasis Research Institute
dc.contributor.institutionHaskins Laboratories, Pace University, New York, New York 10038.
dc.date.accessioned2015-08-18T12:10:07Z
dc.date.available2015-08-18T12:10:07Z
dc.date.issuedJune 1990en
dc.description.abstractPDL-alpha-Difluoromethylornithine is an enzyme-activated inhibitor of ornithine decarboxylase and an antagonist of polyamine metabolism that has been successful in clinical trials against West African sleeping sickness caused by Trypanosoma brucei gambiense. Its potential for use against the more virulent East African form of the disease, caused by T. brucei rhodesiense, is not certain. We examined 14 East African clinical isolates from the Kenya Trypanosomiasis Research Institute strain bank plus 2 established isolates for susceptibility to DL-alpha-difluoromethylornithine and to standard trypanocides. Seven of 16 strains were partially or totally refractory to DL-alpha-difluoromethylornithine in our test system. Four strains were also refractory to arsenical drugs, and five were refractory to diamidines. The results indicate that other novel agents or combinations of established agents may be needed for chemotherapy of East African disease.progressing disease although also invariably fatal if not treated.en
dc.description.sponsorshipPublic Health Service grand from the National Institute of Health
dc.identifier.citationBacchi, C. J., Nathan, H. C., Livingston, T., Valladares, G., Saric, M., Sayer, P. D., & Clarkson, A.B. Jr. (1990). Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense. Antimicrobial Agents and Chemotherapy, 34(6), 1183-1188. https://doi.org/10.1128/aac.34.6.1183 en
dc.identifier.doihttps://doi.org/10.1128/aac.34.6.1183
dc.identifier.issn0066-4804*
dc.identifier.urihttps://kalroerepository.kalro.org/handle/0/10137
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subject.agrovocSusceptibility to infectionen
dc.subject.agrovocTrypanosomes (phytomonas)en
dc.subject.agrovocExperimentsen
dc.subject.agrovocEnzyme inhibitorsen
dc.subject.agrovocDecarboxylasesen
dc.subject.agrovocAntagonismen
dc.titleDifferential Susceptibility to DL-a-Difluoromethylornithine in Clinical Isolates of Trypanosoma brucei rhodesienseen
dc.typeJournal Contribution*
dc.type.refereedRefereeden
dc.type.specifiedArticleen
person.affiliation.nameHaskins Laboratories and Department of Biology, Pace University, New York, Department of Medical and Molecular Parasitology, New York University Medical Centre, Kenya Trypanosomiasis Research Institute Muguga, Kenyaen

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