An Experiment on Dosage in Human Trypanosomiasis

Abstract

The experimf'llt reported in this paper arose out of investigations of two strains of trypanosomes undertaken at the request of another institute because, though both strains had been believed to be non-infective to man, one had apparently infected a laboratory worker. Later, an African assistant in a laboratory through which the strains had passed on their \vay to be tested was also infected by an accident with a syringe while passing the strains. When it had been shown which of the strains was infective to man, it was decided, because two men had been accidentally infected, to determine as nearly as possible how many trypanosomes were needed to produce infection in man by subcutaneous inoculation.