Animal Health
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Browsing Animal Health by Author "Adusu, E."
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Item The Effect of Chemo-Immunotherapy with SDDS, Pyrimethamine and Anti-Toxoplasma Serum on Toxoplasma Gondii Cysts in Latent Infected NMRI Mice(1977) Werner, H.; Masihi, K.N.; Tischer, I.; Adusu, E.; Robert Koch-Institut, Berlin, Fachgebiet: Medizinische ParasitologieA substantial reduction of brain cyst numbers could be obtained through a six-week therapy with SDDS-pyrimethamine combination or a high titer anti-Toxoplasma serum. NMRI mice experimentally infected three months earlier with cyst-forming Toxoplasma strains Witting, Alt or Gail were used. The effectiveness of the treatments could be increased considerably by simultaneous administration of anti-Toxoplasma serum and SDDS-pyrimethamine. A highly significant reduction of brain cyst numbers, up to 65%, could be obtained by using this mode of chemoimmunotherapy. The effectiveness of the treatments used varied amongst the three Toxoplasma strains.
